The Chinese e-commerce giant could not be immediately reached for comment.
Citing an employee with knowledge of the matter, the report said it was not clear if there would be more layoffs, after some of the laid-off staff chose to leave voluntarily and a few relocated.
The commercial division was hit the hardest, according to the report.
AliExpress Russia, a joint venture launched in 2019 by Alibaba and Russian partners, operates domestic and cross-border transactions.
The company depends on cross-border sales for more than three-quarters of its business and has been slower to benefit from a pandemic-led e-commerce boom as supply chains adjust to new travel curbs.
It has also been impacted by the fallout from the Russia-Ukraine war.