City ended the season with 98 points, just two shy of last season's record-breaking 100, while Liverpool's 2-0 victory over Wolverhampton Wanderers saw them end on 97 -- by far the largest tally for a Premier League runners-up.
Needing a 14th successive league win to be certain of prevailing in an unprecedented title duel, City fell behind to Glenn Murray's 27th minute header but Pep Guardiola's side responded in devastating fashion.
Sergio Aguero levelled 83 seconds later and Aymeric Laporte's header put City ahead before the break.
With Liverpool, who began the day one point behind, leading, the Anfield club would still have hoped for something extraordinary to happen in the south coast sunshine.
But when Riyad Mahrez drove an unstoppable shot past Brighton keeper Mathew Ryan's despairing dive just past the hour, City's fans could finally get the party started.
Ilkay Gundogan's majestic free kick made it 4-1 to put the icing on another glorious day for City who are the first club to retain the Premier League title for 10 years.