But international travel curbs on southern Africa, where the new Omicron coronavirus variant was first identified, have blown expectations of a bumper tourist season out of the water.
The multi-storey, white luxury liner is the first to dock at Cape Town since South Africa imposed a total ban on all cruise ships entering local ports in March 2020 after the first coronavirus infection in the country.
A succession of tough lockdown curbs has hammered a local tourism sector dependent on foreign tourists as businesses closed their doors and shed thousands of hospitality jobs.
Now travel restrictions imposed by the European Union, Britain and the United States because of Omicron, designated a variant of concern by the World Health Organisation, have seen the region's three biggest markets cut off.
Owned by German-based travel company TUI Group, the ship carrying hundreds of passengers and crew was sailing from Luderitz in Namibia to Cape Town when news of Omicron broke and raised the possibility that the ship could be re-routed.
"Some passengers (will disembark) to fly home, whilst others will stay on board for the return journey," said Wrenelle Stander, CEO at Wesgro, the trade and investment agency for the Western Cape province.
"Passengers heading to the airport will have to do a PCR (COVID-19) test before leaving," she told Reuters without providing details of passenger numbers or nationalities.
Approximately 157 passengers, who disembarked in small batches, will be processed by immigration services until Thursday according to their flight schedules, said another official. There will be no crew change.
Petra Ruester, who flew to Cape Town from her native Germany last week, waved on the quay side to her parents on board the Europa who will no longer be able to join her onshore to celebrate her birthday on Wednesday.
"My father is very sad... It is a little bit disappointing, but we will celebrate with friends," Ruester said, adding she was in constant contact with her parents via WhatsApp.
Ruester said she expected to have to quarantine for 14 days upon her return to Germany on Dec 4.
The passengers had been expected to visit attractions such as Table Mountain or apartheid-era prison Robben Island, where former president Nelson Mandela was incarcerated.
The ship was originally meant to stay in port until Dec 2 but will now leave a day later as passengers are being tested in a state-run laboratory in the cruise terminal.
"This has been a hammer blow to our major job-creating sector in the province precisely when we needed a recovery, to claw back jobs lost over the last 19 months," said Alan Winde, Premier of the Western Cape province.
The summer season is vital for Cape Town, which lost an estimated 75,000 tourism jobs in the pandemic, officials said.